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. 2020 Nov 11;21(22):8491. doi: 10.3390/ijms21228491

Table 2.

Pathway analysis of common genes analyzed by WebGestalt (KEGG, Panther, and Reactome databases).

Description FDR Description FDR
miR-9-5p KEGG Focal adhesion 0.021 miR-124-3p KEGG Apelin signaling pathway 0.012
Prostate cancer 0.021 Cellular senescence 0.012
ErbB signaling pathway 0.021 Axon guidance 0.012
Cellular senescence 0.021 Pathways in cancer 0.012
Regulation of actin cytoskeleton 0.021 Panther x
MicroRNAs in cancer 0.021 Reactome Receptor-type tyrosine-protein phosphatases 0.031
Neurotrophin signaling pathway 0.021 NOTCH2 Activation and Transmission of Signal to the Nucleus 0.031
Hepatocellular carcinoma 0.021 Semaphorin interactions 0.031
Panther Ras Pathway 0.009 Signaling by Receptor Tyrosine Kinases 0.031
Reactome X Signaling by MET 0.031
MiR-21-5p KEGG Proteoglycans in cancer 0.019 MiR-138-5p KEGG X
Ras signaling pathway 0.032 Panther X
MicroRNAs in cancer 0.038 Reactome X
Neurotrophin signaling pathway 0.043 MiR-1-3p KEGG MicroRNAs in cancer 0.000
EGFR tyrosine kinase inhibitor resistance 0.043 Adherens junction 0.010
Panther X Bacterial invasion of epithelial cells 0.010
Reactome Signaling by NTRK2 (TRKB) 2.62 × 10−3 Axon guidance 0.029
Signaling by NTRKs 2.62 × 10−3 Proteoglycans in cancer 0.029
Signaling by BMP 2.69 × 10−3 EGFR tyrosine kinase inhibitor resistance 0.035
Signaling by Receptor Tyrosine Kinases 4.94 × 10−3 Choline metabolism in cancer 0.035
MET activates PI3K/AKT signaling 4.94 × 10−3 Regulation of actin cytoskeleton 0.035
PI-3K cascade:FGFR3 5.14 × 10−3 Hepatitis B 0.035
PI-3K cascade:FGFR4 5.97 × 10−3 Cocaine addiction 0.042
Signaling by FGFR3 5.97 × 10−3 Viral carcinogenesis 0.042
Signaling by FGFR4 5.97 × 10−3 Renal cell carcinoma 0.042
Signaling by EGFR 5.97 × 10−3 Hippo signaling pathway 0.042
Signaling by FGFR3 in disease 5.97 × 10−3 Spliceosome 0.043
Signaling by FGFR3 point mutants in cancer 5.97 × 10−3 Human papillomavirus infection 0.044
PI-3K cascade:FGFR2 6.63 × 10−3 Thyroid cancer 0.044
Downstream signaling of activated FGFR3 8.67 × 10−3 Cellular senescence 0.044
Signaling by FGFR3 fusions in cancer 9.29 × 10−3 Pathogenic Escherichia coli infection 0.044
Signaling by FGFR1 9.29 × 10−3 Panther X
Downstream signaling of activated FGFR4 9.77 × 10−3 Reactome Signaling by Receptor Tyrosine Kinases 0.000
Signaling by FGFR4 in disease 0.010 Clathrin-mediated endocytosis 0.010
GAB1 signalosome 0.010 RHO GTPases Activate WASPs and WAVEs 0.010
PIP3 activates AKT signaling 0.010 Signaling by VEGF 0.013
Downstream signaling of activated FGFR2 0.012 RNA Polymerase II Transcription 0.028
Signaling by FGFR in disease 0.020 VEGFA-VEGFR2 Pathway 0.028
Intracellular signaling by second messengers 0.022 Gene expression (Transcription) 0.035
MAPK family signaling cascades 0.022 Signaling by RAS mutants 0.035
Signaling by TGF-beta family members 0.022 Diseases of signal transduction 0.035
Signaling by FGFR1 in disease 0.025 EPH-Ephrin signaling 0.041
Interleukin-4 and Interleukin-13 signaling 0.028 Generic Transcription Pathway 0.041
Constitutive Signaling by Aberrant PI3K in Cancer 0.028 Platelet activation, signaling and aggregation 0.042
Signaling by FGFR2 0.031 RHO GTPase Effectors 0.042
Signaling by FGFR2 in disease 0.034 EPHB-mediated forward signaling 0.042
Diseases of signal transduction 0.034 Hemostasis 0.045
Generic Transcription Pathway 0.035 Regulation of actin dynamics for phagocytic cup formation 0.048
PI3K Cascade 0.035 Membrane Trafficking 0.049
Signaling by NODAL 0.038
Gene expression (Transcription) 0.038
MET activates PTPN11 0.039
PI-3K cascade:FGFR1 0.040
IRS-mediated signalling 0.042

Pathways directly involved in cancer are marked in bold. Each miRNA section is separated by color. X—no results obtained. KEKEGG, Pa—Panther, ReReactome.