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Schematic representation of the secondary structure of the monomeric and dimeric TCR-CD3-targeting aptamers: ZUCH-1 (a), OSJ-T1 (b), OSJ-T3_LNA-OMe with LNA and 2′-OMe RNA residues (c), bivalent OSJ-T3_LNA-OMe (d). LNA and 2′-OMe RNA nucleobases are marked in red and blue, respectively. Figures were adapted from Freage et al. [195] with permission.
