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. 2020 Nov 11;12(11):3339. doi: 10.3390/cancers12113339

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Lipid synthesis and particularly lipid metabolism are increased as prostate cancer evolves from HSPC to CRPC to ENZR CRPC. Graphs of gene set enrichment analysis of pathways implicated in lipid synthesis in HSPC cells (LNCaP) (A), CRPC cells (16D) (B), ENZR (49C) (C) and ENZR (49C) (D) (= 1). Fold change of NES (normalized enrichment score) of pathways implicated in lipid synthesis in CRPC cells and ENZR cells relative to HSPC cells. (E) The black arrow indicates change in genes related to lipid biosynthesis (Reactome Metabolism of lipids).