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. 2020 Nov 17;25(22):5365. doi: 10.3390/molecules25225365

Table 1.

Summary of studies pertaining to the anticancer/cytotoxic activity of mangrove-derived Streptomyces during the period 2008–2019.

No. Author Strain Source Compound/Crude Extract IC50 (µg/mL)
Pure Compound
1. Xie et al. [99] Streptomyces sp. 124092 Mangrove rhizosphere soil of Heritiera littoralis (China)
  • (1)

    p-tolyl 3-aminopropanoate *

  • (2)

    6-amino-3-(4-hydroxybenzyl)-1,4-diazonane-2,5-dione *

  • (3)

    n-butyl mannoside

  • (4)

    daidzein

 SMMC-7721 cells: (1) 22.0; (2) 60.0; (3) 13.6; (4) 6.0
2. Yuan et al. [100] Streptomyces sp. 211726 Mangrove rhizosphere soil of Heritiera globosa (China)
  • (1)

    Azalomycin F4a 2-ethylpentyl ester *

  • (2)

    Azalomycin F5a 2-ethylpentyl ester *

 HCT-116 cells: (1) 5.64; (2) 2.58
3. Fu et al. [101] Streptomyces sp. FMA Mangrove soil (China)
  • (1)

    Streptocarbazole A *

  • (2)

    Streptocarbazole B *

 HL-60 cells: (1) 0.67 a
A549 cells: (1) 2.41 a
HeLa cells: (1) 16.61 a; (2) 10.47 a
4. Cibi and Nair [132] Streptomyces parvulus CBJ1 Mangrove soil (India) Actinomycin D A549 cells: 0.52
5. Fu et al. [124] Streptomyces antibioticus strain H74-21 Sediment from a mangrove site (China) Streptomyceamide C * MCF-7 cells: 27.0
6. Mangamuri et al. [125] Streptomyces cheonanensis VUK-A Sediment from Coringa mangrove ecosystem (India) 2-Methyl butyl propyl phthalate * MCF-7 cells: 1391.7
MDA-MB-231 cells: 278.34
HeLa cells: 27.834
OAW-42 cells: 278.34
7. Zhang et al. [123] Streptomyces anandii H41-59 Sediment from a mangrove district (China)
  • (1)

    Ananstrep A *

  • (2)

    Ananstrep B *

  • (3)

    Ananstrep C *

  • (4)

    Ergosta-7,22-diene-3β,5α,6β,25-tetraol

  • (5)

    Ergosta-7,22-diene-3β,5α,6β-triol

  • (6)

    Ergosta-7,22-diene-3β,5α,6α-triol

  • (7)

    Ergosta-7,22-diene-3β,5α,6β,9α-tetraol

  • (8)

    5α,6α-epoxy-ergosta-8(9),22-diene-3β,7α-diol

  • (9)

    5α,6α-epoxy-ergosta-8(14),22-diene-3β,7α-dio

  • (10)

    Ergosta-8(9),22-diene-3β,5α,6β,7α-tetraol

  • (11)

    Ergosta-8(14),22-diene-3β,5α,6β,7α-tetraol

  • (12)

    Ergosta-5,7,22–triene-3β-ol


5β,6β-epoxy-ergosta-8(14),22-diene-3β,7β-diol		 MCF-7 cells: all compounds exhibited > 50; except (3) 18.1, (8) 24.3, (10) 17.3, and (11) 27.4
SF-268 cells: all compounds exhibited > 50; except (3) 13.0, (8) 15.5, (10) 27.8, and (11) 25.1
NCl-H460 cells: all compounds exhibited > 50; except (3) 23.5, (8) 19.8, (10) 23.7, and (11) 23.7
8. Han et al. [102] Streptomyces sp. 219807 Mangrove soil (China)
  • (1)

    Halichoblelide D *

  • (2)

    2-methyl-11,11′-O-dimethylelaiophylin

  • (3)

    2-methylelaiophylin

  • (4)

    Elaiophylin

  • (5)

    11-O-methyl-elaiophylin

  • (6)

    11,11′-O-dimethylelaiophylin

  • (7)

    Efomycin G

 HeLa cells: (1) 0.27 a; (2) 1.20 a; (3) 0.30 a; (4) 0.30 a; (5) 0.59 a; (6) 0.60 a; (7) 0.60 a
MCF-7 cells: (1) 0.30 a; (2) 2.26 a; (3) 0.30 a; (4) 0.19 a; (5) 1.00 a; (6) 1.01 a; (7) 0.80 a
9. Hu et al. [119] Streptomyces antibioticus H12-15 Sediment from a mangrove district (China)
  • (1)

    Neoantimycin A *

  • (2)

    Neoantimycin B *

  • (3)

    Antimycin A1ab

  • (4)

    Antimycin A2a

  • (5)

    Antimycin A9

 MCF-7 cells: (1) >50; (2) >50; (3) 18.1; (4) 36.4; (5) 26.1
SF-268 cells: (1) 33.6; (2) 41.6; (3) <1.6; (4) <1.6; (5) <1.6
NCl-H460 cells: (1) >50; (2) >50; (3) 21.7; (4) 43.7; (5) 15.5
Crude Extract
10. Ravikumar et al. [126] Streptomyces sp. ACT01, ACT02, ACT03, ACT04, and ACT 05 Mangrove sediment from Manakkudi mangrove ecosystem (India) Crude ethyl acetate extract MCF-7 cells: (ACT01) 19.49; (ACT02) 29.94; (ACT03) 75.54; (ACT04) 66.04; (ACT05) 92.64
MDA-MB-231 cells: (ACT01) 32.79; (ACT02) 69.84; (ACT03) 84.09; (ACT04) >100; (ACT05) >100
11. Ser et al. [33] Streptomyces pluripotens MUSC 137T Mangrove soil (Malaysia) Crude methanol extract MCF-7 cells: 61.33
HCT-116 cells: 83.72
A549 cells: 147.20
Ca Ski cells: 300.50
HT-29 cells: 300.98
Caco-2, SW480 and DU145 cells: >400
12. Tan et al. [29] Streptomyces MUM256 Mangrove soil (Malaysia) Crude methanol extract HCT-116 cells: 292.33
HT-29, Caco-2, SW480, MCF-7, A549, DU 145, and Ca Ski cells: b N.P
13. Sanjivkumar et al. [133] Streptomyces olivaceus (MSU3) Mangrove rhizosphere soil of Rhizophora mucronata (India) Crude ethyl acetate extract MCF-7 cells: 88.26
HT-29 cells: 104.81
14. Ser et al. [30] Streptomyces malaysiense MUSC 136T Mangrove soil (Malaysia) Crude methanol extract HCT-116, HT-29, A549, and Ca Ski cells: b N.P.
15. Law et al. [84] Streptomyces colonosanans MUSC 93JT Mangrove soil (Malaysia) Crude methanol extract HCT-116, HT-29, Caco-2, and SW480 cells: b N.P.
16. Ser et al. [134] Streptomyces gilvigriseus MUSC 26T Mangrove soil (Malaysia) Crude methanol extract HCT-116, HT-29, Caco-2, and SW480 cells: b N.P.
17. Law et al. [135] Streptomyces monashensis MUSC 1JT Mangrove soil (Malaysia) Crude methanol extract HCT-116 and SW480 cells: b N.P.
17 Law et al. [75] 11 strains of Streptomyces sp. Mangrove soil (Malaysia) Crude methanol extract HCT-116, HT-29, Caco-2, and SW480 cells: b N.P.
18 Tan et al. [127] Streptomyces sp. MUM256 Mangrove soil (Malaysia) Ethyl acetate extract (further study from Tan et al. [29]) HCT-116: 88.44
19 Tan et al. [3] Streptomyces sp. MUM 265 Mangrove soil (Malaysia) Crude methanol extract HT29 and Caco-2: b N.P.

* new compound identified in the study. a IC50 value is converted to µg/mL based on the calculation of given data in the study; b N.P = IC50 value is not provided in the study. Note: cytotoxic activity was analysed using the MTT method involving human cancer cell lines (SMMC-7721 = hepatocarcinoma cell line; A549 and NCl-H460 = lung cancer cell lines; HCT-116, HT-29, and SW480 = colon cancer cell lines; HL-60 = leukaemia cell line; MCF-7 and MDA-MB-231 = breast cancer cell lines; SF-268 = glioblastoma cell line; Ca Ski = cervical cancer cell line; DU 145 = prostate cancer cell line; HeLa = cervical cancer cell line; OAW-42 = ovarian cancer cell line).