Table 1.
List of differentially expressed proteins in the CSF of sALS cases compared with age-matched controls using SWATH acquisition on liquid chromatography-tandem mass spectrometry (LC–MS/MS).
| Gene | Accesion | Peptides | %CV | FC | p-Value | |
|---|---|---|---|---|---|---|
| HBB | hemoglobin subunit beta | P68871 | 7 | 105.28 | 0.37 | 0.04 |
| CHGA | chromogranin A | P10645 | 6 | 72.40 | 0.55 | 0.00 |
| E7ERL8 | neurexin 1 | E7ERL8 | 5 | 63.37 | 0.66 | 0.02 |
| CLCC1 | chloride channel CLIC like 1 | Q96S66 | 3 | 33.26 | 0.64 | 0.04 |
| K7ERG9 | complement factor D | K7ERG9 | 3 | 40.73 | 1.41 | 0.02 |
| TECR | trans-2,3-enoyl-CoA reductase | Q9NZ01 | 2 | 42.33 | 0.67 | 0.04 |
| ARHGAP4 | Rho GTPase activating protein | P98171 | 2 | 72.50 | 1.32 | 0.02 |
| FUCA2 | alpha-L-fucosidase 2 | Q9BTY2 | 2 | 56.10 | 1.57 | 0.04 |
| A0A0A0MRJ7 | - | A0A0A0MRJ7 | 2 | 66.71 | 2.12 | 0.00 |
| NCK1 | NECK adaptor protein 1 | P16333 | 1 | 102.16 | 0.35 | 0.04 |
| MTMR5 | SBF1 (MTMR5) SET binding factor 1 | O95248 | 1 | 82.74 | 0.36 | 0.02 |
| COR1C | coronin-1C | Q9ULV4 | 1 | 98.19 | 0.40 | 0.05 |
| ITAV | integrin, alpha 5 | P06756 | 1 | 16.49 | 0.41 | 0.01 |
| PAAF1 | proteasomal ATPase associated factor 1 | Q9BRP4 | 1 | 83.56 | 0.43 | 0.03 |
| ITAL | toll-like receptor 4 | P20701 | 1 | 78.52 | 0.43 | 0.01 |
| MCA3 | eukaryotic translation elongation factor 1 epsilon-1 | O43324 | 1 | 100.07 | 0.45 | 0.04 |
| KPCD | protein kinase C delta type i | Q05655 | 1 | 41.25 | 0.46 | 0.03 |
| THADA | THADA armadillo repeat containing | Q6YHU6 | 1 | 46.64 | 0.48 | 0.01 |
| NHLC2 | NHL repeat-containing protein 2 | Q8NBF2 | 1 | 73.60 | 0.49 | 0.03 |
| PLSI | plastin 1 | Q14651 | 1 | 25.89 | 0.54 | 0.03 |
| RFA2 | replication protein A2 | P15927 | 1 | 93.57 | 0.54 | 0.01 |
| MRPS2 | mitochondrial ribosomal protein S2 | Q9Y399 | 1 | 61.86 | 0.56 | 0.02 |
| GSTP1 | glutathione S-transferase pi1 | P09211 | 1 | 30.22 | 0.57 | 0.04 |
| PITH1 | PITH domain containing 1 | Q9GZP4 | 1 | 60.84 | 0.60 | 0.02 |
| IFIT1 | interferon induced protein with tetratricopeptide repeats 1 | P09914 | 1 | 41.39 | 0.63 | 0.05 |
| H7C3C4 | - | H7C3C4 | 1 | 32.17 | 0.70 | 0.04 |
| MGAT2 | alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Q10469 | 1 | 34.5 | 1.39 | 0.02 |
| AFF4 | AF4/FMR2 familiy member 4 | Q9UHB7 | 1 | 37.83 | 1.39 | 0.03 |
| PGP | phosphoglycolate phosphatase | A6NDG6 | 1 | 20.82 | 1.45 | 0.04 |
| AEBP1 | AE binding protein 1 | Q8IUX7 | 1 | 39.01 | 1.57 | 0.00 |
| PSMG2 | proteasome assembly chaperone 2 | Q969U7 | 1 | 40.08 | 1.60 | 0.03 |
| RAB8A | RAB8A, member RAS oncogene family | P61006 | 1 | 77.36 | 1.66 | 0.01 |
| S10A6 | S100 calcium biding protein A6 | P06703 | 1 | 64.07 | 1.67 | 0.03 |
| A0A2R8Y891 | - | A0A2R8Y891 | 1 | 46.81 | 1.91 | 0.02 |
| LAMP1 | lysosomal associated membrane protein 1 | P11279 | 1 | 99.83 | 1.92 | 0.02 |
| FXRD2 | FAD-dependent oxidoreductase domain containing 2 | Q8IWF2 | 1 | 56.92 | 1.95 | 0.05 |
| SDF1 | C-X-C motif chemokine ligand 12 | P48061 | 1 | 39.23 | 1.97 | 0.00 |
| A0A0A0MS87 | - | A0A0A0MS87 | 1 | 67.51 | 1.98 | 0.04 |
| MGP | matrix Gla protein | P08493 | 1 | 28.51 | 2.00 | 0.00 |
| A0A1B0GVW0 | - | A0A1B0GVW0 | 1 | 60.77 | 2.01 | 0.00 |
| STX12 | syntaxin 12 | Q86Y82 | 1 | 60.13 | 2.01 | 0.04 |
| AT2B4 | ATPase plasma membrane Ca2+ transportin 4 | P23634 | 1 | 59.88 | 2.04 | 0.04 |
| PSDE | proteasome 26S subunit, non-ATPase 14 | O00487 | 1 | 69.53 | 2.12 | 0.04 |
| PCMT1 | protein-l-isoaspartate (D-aspartate) O-methyltransferase | H7BY58 | 1 | 50.17 | 2.14 | 0.03 |
| CH082 | Q6P1X6 | 1 | 52.14 | 2.19 | 0.03 | |
| AAAS | aladin WD repeat nucleoporin | Q9NRG9 | 1 | 59.66 | 2.19 | 0.02 |
| A0A1B0GUA3 | - | A0A1B0GUA3 | 1 | 123.34 | 2.27 | 0.03 |
| OLFL3 | olfactomedin 3 | Q9NRN5 | 1 | 62.69 | 2.57 | 0.00 |
| TAGL | transgelin | Q01995 | 1 | 136.16 | 2.95 | 0.01 |
| NAA15 | N-alpha.-acetyltransferase 15, NatA auxiliary subunit | Q9BXJ9 | 1 | 130.87 | 3.26 | 0.04 |
| J3KPF0 | - | J3KPF0 | 1 | 114.46 | 3.66 | 0.00 |