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Effects (IC50 values in µM) of compounds 333–343 on inhibition of β-hematin formation and activity against cultured Plasmodium falciparum parasites.
| Compound | Inhibition of β-Hematin Formation | Inhibition of P. Falciparum Parasites |
|---|---|---|
| IC50 Values (µM) | IC50 Values (µM) | |
| 333 | - | >10 |
| 334 | - | 1 |
| 335 | - | >10 |
| 336 | - | >10 |
| 337 | - | >10 |
| 338 | 14.48 | >10 |
| 339 | 8.65 | >10 |
| 340 | 0.67 | >10 |
| 341 | - | >10 |
| 342 | 0.48 | >10 |
| 343 | 0.50 | >10 |
