Figure 5.

Role of antioxidant systems and enzyme cofactors in the management sepsis and ROS formation. Abbreviations: O₂⁻ = superoxide anion, NO = nitric oxide, Zn = zinc, SOD = superoxide dismutase, H₂O₂ = hydrogen peroxide, OH = hydroxyl radical, NAC = N-acetylcysteine, MT = melatonin, GSH = glutathione, GSSG = oxidized glutathione, GR = glutathione reductase, GPx = glutathione peroxidase, TNFαSRp55 = soluble α receptor tumor necrosis factor p55, MOF = multiple organ failure, LPO = lipoperoxidation, CRP = C reactive protein, SOFA = sequential organ failure assessment.