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. 2020 Nov 17;12(11):3407. doi: 10.3390/cancers12113407

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Sting expression in tumor cells is essential to induce oncolytic virus-mediated immunogenic cell death. Evaluation of extracellular ATP (A) and HMGB1 (B) released in supernatant of mock or OV (oncolytic virus)-infected LLC1-HER2 and Sting knockout cells. Viral doses are indicated in each panel (1 and 10 PFU/cell). Infections were performed as biological replicates. The statistical significances for experiments described in Figure 6 were calculated by Student’s t-test. Panel A, the p-values were: 0.0008 comparing untreated and 1 MOI LLC1-HER2; 0.01 comparing untreated and 10 MOI LLC1-HER2_SKO. Panel B, the p-value was 0.0199 comparing untreated and 10 MOI LLC1-HER2. Ns indicates statistically not significant differences calculated by Student’s t-test. p < 0.05 *; p < 0.005 **.