Table 3.

Independent predictors of high risk QTc prolongation (peak QTc ≥ 500 ms and/or ΔQTc ≥60ms).

	Odds ratio (CI 95%)	p-value	Adjusted Odds ratio (CI 95%)	p-value
Female	1.14 (0.53–2.47)	0.739
Triple therapy	1.98 (0.80–4.91)	0.139
Other QTc interfering drugs*	1.53 (0.51–4.60)	0.449
Loop diuretic	3.02 (1.23–7.42)	0.016	1.79 (0.62–5.21)	0.284
Hypokalemia (K+ ≤ 3.5 mEq/L)	3.78 (1.65–8.66)	0.002	4.0 (1.61–9.95)	0.003
Heart failure	1.48 (0.61–3.57)	0.389
Baseline QTc ≥450 ms	1.36 (0.49–3.72)	0.553
Sepsis	3.67 (1.32–10.2)	0.013	2.65 (0.88–7.99)	0.083

QTc: corrected QT interval, ms: milliseconds. *: Levofloxacin, Amiodarone, Haloperidol, Venlafaxine, Famotidine.