Table 5. Fractional inhibitory concentration indexes (FICI) of human defensins in combination with amikacin (AMN) against E. coli isolates.
| E. coli isolates | FICI | ||
|---|---|---|---|
| HNP-1 + AMN | hBD-1 + AMN | hBD-3 + AMN | |
| EC-1 | 0.5 | – | 0.5 |
| EC-2 | 0.375 | – | 0.375 |
| EC-3 | 0.25 | – | 0.5 |
| EC-4 | 0.375 | – | 0.5 |
| EC-5 | 0.375 | 1 | 0.75 |
| EC-6 | 0.75 | 1 | 0.375 |
| EC-7 | 0.375 | – | 0.5 |
| EC-8 | 0.5 | 1.5 | 0.5 |
| EC-9 | 0.375 | 0.75 | 0.375 |
| EC-10 | 0.5 | 0.375 | 0.5 |
| EC-11 | 0.75 | 0.75 | 0.375 |
| EC-12 | 0.5 | – | 0.5 |
| EC-13 | 0.625 | 1 | 0.75 |
| EC-14 | 0.375 | 0.75 | 0.5 |
| EC-15 | 0.5 | – | 0.5 |
| EC-16 | 0.5 | 1 | 0.5 |
| EC-17 | 0.25 | 1.5 | 0.5 |
| EC-18 | 0.5 | 2 | 0.5 |
| EC-19 | 0.375 | 1.5 | 0.375 |
| EC-20 | 0.5 | 1.5 | 0.5 |
| EC-21 | 0.375 | – | 0.5 |
| EC-22 | 0.25 | 1.5 | 0.375 |
| EC-23 | 0.375 | – | 0.5 |
| EC-24 | 0.3125 | – | 0.375 |
Note:
FICI ≤ 0.5—synergistic effect; 0.5 < FICI < 4—no interaction; FICI > 4—antagonism; in some cases of hBD-1 + AMN combination FICI has not been calculated—since MIC values of hBD-1 were > 64 mg/L.