Table 1.
Antimicrobial susceptibility profiles of metallo-β-lactamase (MBL)-producing Enterobacteriaceae.
| Patient | 1 | 2 | 3 | 4 |
|---|---|---|---|---|
| Sex | F | M | F | M |
| Age (years) | 60 | 34 | 84 | 70 |
| Date of isolation | 7/5/2018 | 25/7/2018 | 4/9/2018 | 16/12/2018 |
| Sample | Pharyngeal mucus | Faeces | Urine | Faeces |
| Species | E. cloacae | K. pneumoniae | E. cloacae | K. oxytoca |
| Strain number | TK1601 | TK1602 | TK1603 | TK1604 |
| MLST | ST252 | ST70 | ST78 | ST88 |
| Plasmid Inc | FIB, HI2 | FIB, HI1 | FIB, HI2, L/M | FIB, HI2 |
| Carbapenemase | IMP-1 | VIM-1 | IMP-10 | IMP-1 |
| ESBL | – | – | CTX-M-1 | – |
| Antimicrobial agent | MIC (mg/L) a | |||
| Penicillins | ||||
| Ampicillin | >16 | >16 | >16 | >16 |
| Piperacillin | >64 | >64 | >64 | 64 |
| Sulbactam/ampicillin | >16 | >16 | >16 | >16 |
| Amoxicillin/clavulanic acid | >16 | >16 | >16 | >16 |
| Tazobactam/piperacillin | >64 | >64 | >64 | 8 |
| Cephalosporins | ||||
| Cefazolin | >16 | >16 | >16 | >16 |
| Cefotiam | >16 | >16 | >16 | >16 |
| Cefotaxim | >2 | >2 | >2 | >2 |
| Ceftazidime | >16 | >16 | >16 | >16 |
| Ceftriaxone | >2 | >2 | >2 | >2 |
| Cefepime | >16 | 16 | >16 | 16 |
| Cefozopran | >16 | >16 | >16 | 8 |
| Cefmetazole | >32 | >32 | >32 | >32 |
| Cefaclor | >16 | >16 | >16 | >16 |
| Cefdinir | >2 | >2 | >2 | >2 |
| Cefpodoxime | >4 | >4 | >4 | >4 |
| Cefcapene | >2 | >2 | >2 | >2 |
| Flomoxef | >32 | >32 | >32 | 32 |
| Sulbactam/cephoperazon | >32 | >32 | >32 | >32 |
| Carbapenems | ||||
| Doripenem | 4 | 8 | >8 | >8 |
| Imipenem | 4 | 4 | >8 | 4 |
| Meropenem | 4 | 4 | >8 | 8 |
| Monobactam | ||||
| Aztreonam | 4 | 8 | >16 | 4 |
| Fluoroquinolones | ||||
| Ciprofloxacin | 0.25 | 0.25 | >2 | 1 |
| Levofloxacin | 0.5 | 0.5 | >4 | 2 |
| Sitafloxacin | 1 | 1 | >2 | 1 |
| Aminoglycosides | ||||
| Gentamicin | 2 | 8 | 8 | 2 |
| Tobramycin | 8 | >8 | 8 | 4 |
| Amikacin | 4 | 8 | 4 | 4 |
| Tetracycline Minocycline |
>8 | 2 | >8 | 8 |
| Polymyxin | ||||
| Colistin | NT | 2 | NT | 2 |
| Other | ||||
| Fosfomycin | 16 | >16 | >16 | 16 |
| Trimethoprim/sulfamethoxazole | 2 | >2 | >2 | 2 |
a Values in bold indicate resistant; NT, not tested.