Table 4.
Comparison of the 2-Year Follow-Up Data of the Four Groups Using Generalized Estimating Equation
| Variables | Central Macular Thickness | |||
|---|---|---|---|---|
| b | SE | 95% CI | P-value | |
| Interception | 273.13 | 34.76 | 205.00, 341.26 | <0.001 |
| Group | ||||
| DRT | Reference | |||
| CME | 71.06 | 14.07 | 43.48,98.63 | <0.001 |
| SRD | 182.85 | 25.71 | 132.47, 233.24 | <0.001 |
| VMIA | 82.79 | 12.60 | 58.10, 107.49 | <0.001 |
| Time after treatment | ||||
| 1 month | −30.78 | 7.98 | −46.41,−15.42 | <0.001 |
| 3 months | −17.44 | 9.99 | −37.03,2.14 | 0.081 |
| 6 months | −9.75 | 7.37 | −24.19,4.69 | 0.186 |
| 12 months | −20.22 | 8.87 | −37.61,−2.84 | 0.023 |
| 24 months | −11.31 | 13.22 | −37.21,14.6 | 0.392 |
| Group x time | ||||
| CME x 1 month | −27.71 | 14.83 | −56.78,1.36 | 0.062 |
| CME x 3 month | −61.90 | 15.64 | −92.55,−31.25 | <0.001 |
| CME x 6 month | −78.33 | 14.55 | −106.86,−49.80 | <0.001 |
| CME x 12 month | −76.87 | 17.53 | −111.23,−42.51 | <0.001 |
| CME x 24 month | −89.58 | 20.74 | −130.22,−48.94 | <0.001 |
| SRF x 1 month | −154.68 | 23.85 | −201.43,−107.92 | <0.001 |
| SRF x 3 month | −208.32 | 27.73 | −262.66,−153.98 | <0.001 |
| SRF x 6 month | −187.23 | 24.42 | −235.09,−139.37 | <0.001 |
| SRF x 12 month | −205.09 | 27.50 | −258.99,−151.19 | <0.001 |
| SRF x 24 month | −195.77 | 30.15 | −254.86,−136.67 | <0.001 |
| VMIA x 1 month | −0.513 | 13.50 | −26.97,25.95 | 0.970 |
| VMIA x 3 month | −23.83 | 16.55 | −56.28,8.62 | 0.150 |
| VMIA x 6 month | −33.02 | 13.15 | −58.80,−7.25 | 0.012 |
| VMIA x 12 month | −21.28 | 14.94 | −50.56,8.01 | 0.154 |
| VMIA x 24 month | −69.55 | 19.44 | −107.66,−31.44 | <0.001 |
| Gender | ||||
| Male | Reference | |||
| Female | −12.83 | 8.15 | −28.81,3.15 | 0.115 |
| Age | 0.50 | 0.42 | −0.31,1.32 | 0.228 |
| PRP | −10.62 | 9.49 | −29.22,7.98 | 0.263 |
| High Myopia | 9.79 | 23.81 | −36.88,56.46 | 0.681 |
| Smoking | −3.01 | 11.43 | −25.42,19.40 | 0.792 |
| Alcohol | −21.24 | 12.20 | −45.16,2.68 | 0.082 |
| HbA1c | 0.25 | 3.41 | −6.43,6.93 | 0.942 |
| Hypertension | −4.62 | 8.38 | −21.05,11.81 | 0.581 |
| CAD | 50.85 | 13.94 | 23.52,78.17 | <0.001 |
| Stroke | −18.86 | 19.45 | −56.98,19.25 | 0.332 |
| CKD | 14.38 | 8.39 | −2.08,30.83 | 0.087 |
| Thyroid | −13.49 | 17.76 | −48.30,21.32 | 0.448 |
| Cancer | 4.53 | 19.85 | −34.38,43.43 | 0.820 |
| Hyperlipidemia | 26.45 | 9.88 | 7.09,45.80 | 0.007 |
| OCT Finding: | ||||
| IS/OS disruption | −9.36 | 13.75 | −36.31,17.58 | 0.496 |
| HRDs | 17.09 | 7.84 | 1.72,32.45 | 0.029 |
Abbreviations: PRP, panretinal photocoagulation; CAD, coronary artery disease; CKD, chronic kidney disease; DRT, diffuse retinal thickening; CME, cystoid macular edema; SRD, serous retinal detachment; VMIAs, vitreomacular interface abnormalities; IS/OS, inner segment/outer segment; HRDs, hyperreflective dots.