Table 2.
NF-κB p65 activation scores in macrophages infected with MAP or treated with LPS following treatment with RHB-104 and its major components.
| Treatment | Antibiotic Concentration (µg/mL) | NF-κB p65 Activation Score (%) |
|---|---|---|
| Positive Control | - | 100.0 |
| Negative Control | - | 6.9 |
| MAP + RHB-104 | 0.50 | 48.4 |
| 1.00 | 21.5 | |
| 2.00 | 13.4 | |
| MAP + CLA | 0.32 | 58.3 |
| 0.63 | 49.6 | |
| 1.26 | 24.1 | |
| MAP + RIF | 0.15 | 83.8 |
| 0.30 | 73.1 | |
| 0.60 | 57.5 | |
| LPS + RHB-104 | 0.5 | 67.2 |
| 1.0 | 37.8 | |
| 2.0 | 23.3 | |
| LPS + CLA | 0.32 | 68.2 |
| 0.63 | 57.2 | |
| 1.26 | 33.6 | |
| LPS + RIF | 0.15 | 89.1 |
| 0.30 | 83.4 | |
| 0.60 | 68.7 |