Figure 6.

Effect of His-functionalized bola dendrimers on the bioactivity of U87 glioblastoma cells. U87 cells were cultivated in the presence of 10a or 12a (1P200 μM) for 96 h after the administration of the agents and their numbers were counted with a Coulter counter. All data are shown as mean ± SD. Statistical significance of the differences tested with Two-way ANOVA, * p < 0.01. Data representative for at least 3 independent experiments (n > 3). Scale bar: 50 μm. Note the relatively high cytostatic activity of ester-bound amphiphilic dendrimer 12a in the U87 model.