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. 2020 Nov 18;12(11):1106. doi: 10.3390/pharmaceutics12111106

Scheme 4.

Scheme 4

Synthesis of bola dendrimers 11a and 12a. Reagents/conditions: (f) HCl/EtOAc, 8 h, r.t.; (g) Fmoc-Pro-OH, DCC/HOSu, THF, 126 h, r.t.; (h) Fmoc-His(Boc)-OH, DCC/HOSu, THF, 126 h, r.t.; (i) HCl/EtOAc, 8 h, r.t.; (j) tris(2-aminoethyl)amine/MeOH, 8 h, r.t.