3D	Three-dimensional
DAPI	4′,6-diamidino-2-phenylindole
DMEM	Dulbecco’s modified Eagle’s medium
ECM	Extracellular matrix
EGF	Epidermal growth factor
MMP	Matrix metalloproteinase
IF	Immunofluorescence
IHC	Immunohistochemistry
KO	Knockout
R-SMAD	Receptor-regulated SMAD
RT-PCR	Reverse transcription-polymerase chain reaction
TGF-β	Transforming growth factor-β
TNC	Tenascin C
WT	Wild-type