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. 2020 Nov 18;21(22):8687. doi: 10.3390/ijms21228687

Figure 1.

Figure 1

Schematic representation of human metallocarboxypeptidase Z (CPZ) and its recombinant forms. Full-length human CPZ (UniProtKB accession number Q66K79) and the recombinant CPZ forms used in this work are represented. Key residues essential for the catalytic mechanism are indicated: His69, Glu72, Arg145, His198 and Glu270 (numbering based on the mature form of bovine CPA, by convention in the field). Positions of residues Ser387, D391 and Ser457 of CPZ (equivalent to Leu203, Gly207 and Ile255 in bovine CPA, respectively) are also indicated. The recombinant form CPZ lacks 29 residues in its C-terminal region. The recombinant form CPZΔFz, in addition to the C-terminal truncation, lacks 167 residues in its N-terminal tail, corresponding to the Frizzled-like (Fz) domain.