Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 18;21(22):8687. doi: 10.3390/ijms21228687

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Structural modeling of the Fz domain of human CPZ and its interaction with Wnt-8. (A) Ribbon representation of the highly conserved N-terminal Fz domain of human CPZ; (B) Structural comparison of the Fz domain of human CPZ (Fz-CPZ, represented in blue) and the cysteine-rich domain of mouse Fz8 (Fz8-CRD, represented in orange); (C) Structure-based sequence alignment of Fz-CPZ and Fz8-CRD (represented in blue and orange respectively); (D) Ribbon representation of Wnt-8 in a proposed complex with the Fz domain of CPZ. The extended palmitoleic acid (PAM) group is represented with red spheres, and the most important sites of interaction between Fz-CPZ and Fz8-CRD are indicated as Site 1 and Site 2. For all proteins, the N-terminus and C-terminus are indicated as N-t and C-t, respectively.