Table 1.
Top Ten Differentially Expressed Genes Enriched in Cerebral Organoids and Cortical Neuron Cultures, Listed According to Log-Fold Change
| log2(fold_change) | P_value | Gene description | |
|---|---|---|---|
| Genes enriched in organoids | |||
| AMBN | −5.94408 | 5.00E-05 | Ameloblastin |
| CALB2 | −5.41845 | 5.00E-05 | calbindin 2 |
| CPNE6 | −5.16982 | 5.00E-05 | copine 6′ |
| VSTM2A-OT1 | −5.02407 | 0.0128 | VSTM2a overlapping transcript 1 |
| VSTM2A | −4.95297 | 5.00E-05 | V-set and transmembrane domain containing 2A |
| C1QL4 | −4.86432 | 5.00E-05 | complement C1q like 4 |
| SLC32A1 | −4.73084 | 5.00E-05 | solute carrier family 32 member 1 |
| VAX1 | −4.68835 | 0.0033 | ventral anterior homeobox 1 |
| SCGN | −4.56377 | 5.00E-05 | secretagogin, EF-hand calcium-binding protein |
| LOC107987397 | −4.50865 | 5.00E-05 | DNA-directed RNA polymerase II subunit RPB1-like |
| Genes enriched in 2D neurons | |||
| S100A9 | 15.3965 | 0.0003 | S100 calcium-binding protein A9 |
| DMBT1 | 12.5401 | 5.00E-05 | deleted in malignant brain tumors 1 |
| IVL | 12.2895 | 0.00025 | Involucrin |
| ITLN1 | 12.1238 | 0.0003 | intelectin 1 |
| MUC14 | 11.5564 | 5.00E-05 | mucin 13, cell surface associated |
| KRT6A | 11.4887 | 0.0109 | keratin 6A |
| PYY | 11.2089 | 0.0013 | peptide YY |
| CDH17 | 10.9958 | 0.00415 | cadherin 17 |
| CLCA1 | 10.8057 | 5.00E-05 | chloride channel accessory 1 |
| TMPRSS4 | 10.6664 | 0.0012 | transmembrane serine protease 4 |