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. 2020 Nov 18;10(1):24–48. doi: 10.1089/wound.2020.1175

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Copyright 2021, Mary Ann Liebert, Inc., publishers

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Figure 8. — Summary of major cytokines secreted by AD-MSCs. List of predominant cytokines related to the following: 1. immunomodulation: TGF-β, PGE2, IL-6/10, and IDO; 2. vascularization: VEGF, CXCL12, FGF-2, and ANGPT1; 3. innervation: NGF, BDNF, GDNF, and IGF-1; and 4. pleiotropic: HGF, EGF, and PDGF. TGF-β, transforming growth factor-β; PGE2, prostaglandin E2; IL, interleukin; IDO, indoleamine 2,3-dioxygenase; VEGF, vascular endothelial growth factor; CXCL12, C–X–C motif chemokine 12; FGF-2, fibroblast growth factor-2; ANGPT1, angiopoietin-1; NGF, nerve growth factor; BDNF, brain-derived neurotrophic factor; GDNF, glial cell line-derived neurotrophic factor; IGF-1, insulin growth factor-1; HGF, hepatocyte growth factors; EGF, epithelial growth factors; PDGF, platelet derived growth factor. Color images are available online.