Skip to main content
. 2020 Nov 18;9(11):1143. doi: 10.3390/antiox9111143

Figure 6.

Figure 6

The combined effect of MEL and ABT-737 on the level of ER stress markers—Protein disulfide isomerase (PDI) (a), binding immunoglobulin protein (BIP) (b) ER oxidoreductin 1-Lα (ERO1-Lα) (c), protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) (d) and the activating transcription factor ATF4 (e) in HL-60 cells. Cells were treated with 0.7 µM ABT-737 (column 2), and 0.2 µM ABT-737 (columns 3) and 1 mM MEL (column 4), and MEL in combination with 0.2 µM ABT-737 (column 5); untreated cells (control, column 1). The ratio of protein levels to GAPDH was used as a loading control. The protein level in the cell lysate without any additives served as a control (100%). “+” means the presence of MEL The data are presented as the means ± S.D. of three separate experiments. * p < 0.05 significant difference in the protein level relative to the control (untreated cells), # p < 0.05 significant difference in the protein level compared to ABT-737 alone (0.2 µM, column 3).