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This table illustrates the study selection criteria.
| Inclusion | Exclusion |
|---|---|
| Brain studies on WMLs with rims presence | Studies published before 2001 |
| Pathological studies | Animal studies |
| Studies published in peer-review journals or the grey literature | Case reports, reviews or systematic literature reviews and qualitative studies, opinion pieces, editorials comments, and news |
| Literature is written in English MRIs field strength reported |
