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Detection of neutrophil-derived citrullinated histone H3-bound DNA produced in response to stimulation with PMA. Neutrophils were isolated from the BM of (a) DP42-bearing mice, (b) 5TGM1-bearing mice, or control tumor-free mice and stimulated with 200 nM PMA for 4 h. The NET fractions were then isolated and used in the CitH3DNA binding assay. Combined data from 3 independent experiments are shown. Mean ± SD values are shown. RFU—relative fluorescence units.
