Table 4.
Generalized Linear Models for NSI Scores
| |
NSI total score |
NSI total score |
NSI somatic |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Predictors | Estimates | SE | p | Estimates | SE | p | Estimates | SE | p |
| (Intercept) | 33.31 | 7.04 | <0.001 | 32.98 | 8.21 | <0.001 | 6.74 | 2.56 | 0.010 |
| Age | -0.09 | 0.17 | 0.601 | -0.08 | 0.16 | 0.621 | 0.01 | 0.05 | 0.774 |
| Gender | -2.93 | 4.29 | 0.496 | -2.66 | 4.03 | 0.511 | -1.24 | 1.26 | 0.328 |
| Total number of TBIs | 1.72 | 0.96 | 0.076 | 1.13 | 0.92 | 0.219 | 0.43 | 0.29 | 0.136 |
| Years since last TBI | -0.13 | 0.23 | 0.576 | -0.11 | 0.21 | 0.595 | -0.06 | 0.07 | 0.398 |
| hsa-miR-139-5p | 1.78 | 0.49 | <0.001 | 0.62 | 0.15 | <0.001 | |||
| hsa-miR-103a-3p | -1.24 | 0.37 | 0.001 | -0.34 | 0.12 | 0.004 | |||
| Pseudo R2 | 0.05 | 0.183 | 0.210 | ||||||
| |
NSI affective |
NSI cognitive |
NSI vestibular |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Predictors | Estimates | SE | p | Estimates | SE | p | Estimates | SE | p |
| (Intercept) |
14.06 |
3.03 |
<0.001 |
7.27 |
1.96 |
<0.001 |
3.37 |
1.24 |
0.007 |
| Age |
-0.06 |
0.06 |
0.301 |
-0.02 |
0.04 |
0.529 |
-0.01 |
0.02 |
0.804 |
| Gender |
-0.45 |
1.49 |
0.762 |
-0.52 |
0.97 |
0.591 |
-0.60 |
0.61 |
0.326 |
| Total number of TBIs |
0.08 |
0.34 |
0.809 |
0.27 |
0.22 |
0.222 |
0.23 |
0.14 |
0.098 |
| Years since last TBI |
-0.04 |
0.08 |
0.641 |
-0.02 |
0.05 |
0.627 |
0.01 |
0.03 |
0.846 |
| hsa-miR-139-5p |
0.54 |
0.18 |
0.003 |
0.25 |
0.12 |
0.031 |
0.21 |
0.07 |
0.005 |
| hsa-miR-103a-3p |
-0.40 |
0.13 |
0.003 |
-0.22 |
0.09 |
0.012 |
-0.20 |
0.05 |
<0.001 |
| Pseudo R2 | 0.139 | 0.116 | 0.182 | ||||||
Generalized linear models including demographics (age and gender) and TBI characteristics (Number of TBIs and time since last TBI) were built to further assess relationships between levels of the miRNAs and NSI Total scores or scores of NSI factors (i.e. Somatic, Affective, Cognitive, Vestibular). Only miRNAs that were significantly correlated with NSI total scores or scores of NSI factors were evaluated. Table represents models including both hsa-miR-103a-3p and hsa-miR-139-5p. In addition, a model including demographics and TBI characteristics, but not miRNA levels, is also shown. Results were shown for the predictors included in each model. p values < 0.05 are bold.
NSI, Neurobehavioral Symptom Inventory; SE, standard error; TBI, traumatic brain injury.