Table 4.

In-Silico Evaluation of the Effect of Hypoglycemia Treatment Recommendations at Bedtime

Glucose control metric	Intervention
Mean ± STD	None	Bedtime snack 15 g			Bedtime snack 15–30 g
n = 10 subjects (3300 nights)		Oracle-based	Bedtime glucose	SVR-based	Oracle-based	Bedtime glucose	SVR-based
Time in hypoglycemia (<3.89 mmol/L), %
Nighttime	6.1 ± 5.9	2.0 ± 2.8a	2.3 ± 2.9a	2.1 ± 2.7a	0.9 ± 1.6a	1.6 ± 2.1a	1.4 ± 2.0a
24 h	3.6 ± 2.4	1.7 ± 1.1a	1.8 ± 1.1a	1.8 ± 1.1a	1.2 ± 0.7a	1.5 ± 0.8a	1.4 ± 0.8a
Time in hyperglycemia (>10 mmol/L), %
Nighttime	30.2 ± 10.4	30.6 ± 10.3	36.5 ± 12.2a,b	33.2 ± 9.9a	31.1 ± 10.0	40.0 ± 13.4a,b	34.2 ± 10.1a
24 h	36.9 ± 9.9	37.2 ± 9.8	39.8 ± 9.9a,b	38.4 ± 9.2a,b	37.4 ± 9.8	41.5 ± 9.9a,b	38.9 ± 9.1a
Time in range (3.89–10 mmol/L), %
Nighttime	63.6 ± 6.5	67.4 ± 8.5a	61.2 ± 10.0b	64.7 ± 8.0b	68.0 ± 9.1	58.4 ± 11.7b	64.4 ± 8.7
24 h	59.5 ± 9.7	61.1 ± 9.2a	58.3 ± 9.3b	59.8 ± 8.7b	61.4 ± 9.2	57.0 ± 9.3b	59.70 ± 8.5

^aStatistically significant difference with respect to no intervention (P < 0.01).

^bStatistically significant difference with respect to oracle-based intervention (P < 0.01).

SVR, support vector regression.