Table 3.
Performance of Plasma GFAP Cutoff Ranges for GCS 13-15 within 24 h of Injurya
| GFAP cutoff (pg/mL) | Sensitivity | Specificity | Positive predictive value | Negative predictive value |
|---|---|---|---|---|
| 13.1 | 0.994 (0.986, 1) | 0.157 (0.131, 0.182) | 0.351 (0.344, 0.359) | 0.985 (0.961, 1) |
| 37.8 | 0.964 (0.944, 0.980) | 0.303 (0.271, 0.340) | 0.389 (0.377, 0.402) | 0.949 (0.921, 0.973) |
| 113.3 | 0.902 (0.869, 0.933) | 0.498 (0.466, 0.530) | 0.452 (0.435, 0.470) | 0.917 (0.891, 0.941) |
| 190.1 | 0.846 (0.810, 0.883) | 0.594 (0.561, 0.630) | 0.490 (0.466, 0.515) | 0.894 (0.872, 0.917) |
a
Optimal cutoffs were selected based on the criteria of adjusted negative predictive value above a range of levels (0.90, 0.92, 0.95, 0.98) using the K-fold cross-validation method.
GFAP, glial fibrillary acidic protein.