Table 3.
Regions in Which Group × Processing Speed Interactions Were Observed
| Size (voxels) | MNI coordinates | Z | q (FDR) | Region(s) |
|---|---|---|---|---|
| Right lobules I–IV | ||||
| 478 | 6, −12, 48 | 4.86 | 5.84 × 10−4 | Bilateral middle cingulate, spanning L supplementary motor area, bilateral precuneus, bilateral postcentral gyrus, bilateral paracentral lobule, medial frontal gyrus, L superior parietal lobule |
| Left lobule V | ||||
| 402 | −9, 9, 42 | 5.25 | 0.0013 | Bilateral middle cingulate, spanning bilateral supplementary motor area, R superior frontal gyrus, R precentral gyrus, medial frontal gyrus, R paracentral lobule, L medial superior frontal gyrus, anterior cingulate |
| 927 | −51, −21, 24 | 4.56 | 5.33 × 10−6 | L supramarginal gyrus, spanning bilateral inferior parietal lobule, bilateral superior parietal lobule, bilateral postcentral gyrus, L Rolandic operculum, middle cingulate, R angular gyrus, L insula, L superior temporal gyrus, R precuneus |
| Right lobule V | ||||
| 2880 | 0, 3, 54 | 5.26 | 1.89 × 10−14 | Bilateral supplementary motor area, spanning bilateral middle cingulate, bilateral inferior parietal lobule, bilateral medial frontal gyrus, bilateral supramarginal gyrus, bilateral precuneus, bilateral postcentral gyrus, bilateral superior parietal lobule, bilateral superior frontal gyrus, L Rolandic operculum, L superior temporal gyrus, L cuneus, bilateral precentral gyrus, bilateral paracentral lobule, bilateral anterior cingulate, L insula, L middle temporal gyrus, bilateral angular gyrus |
| 313 | 54, −21, 24 | 4.50 | 0.0032 | R supramarginal gyrus, spanning R superior temporal gyrus, R postcentral gyrus, R Rolandic operculum, R insula, R superior temporal gyrus |
| Left lobule VIIIa | ||||
| 438 | −51, −48, 33 | 4.78 | 0.0025 | L supramarginal gyrus, spanning L inferior parietal lobule, L superior temporal gyrus, L middle temporal gyrus, L Rolandic operculum, L angular gyrus, L insula, L precentral gyrus |
| 439 | 3, 18, 33 | 4.48 | 0.0025 | Bilateral middle cingulate, spanning bilateral supplementary motor area, L superior frontal gyrus, medial frontal gyrus, R anterior cingulate |
| 436 | 9, −75, 9 | 4.42 | 0.0025 | Bilateral calcarine, spanning bilateral cuneus, L superior occipital gyrus |
| Right lobule VIIIa | ||||
| 946 | −6, −57, 63 | 4.98 | 1.99 × 10−5 | Bilateral precuneus, spanning L inferior parietal lobule, L supramarginal gyrus, L superior temporal gyrus, L superior temporal gyrus, L middle temporal gyrus, bilateral middle cingulate, L superior parietal lobule, L paracentral lobule |
| Left lobule VIIIb | ||||
| 412 | −51, −21, 21 | 4.72 | 0.0021 | L supramarginal gyrus, spanning L superior temporal gyrus, L postcentral gyrus, L middle temporal gyrus, L inferior parietal lobule, L Rolandic operculum, L middle temporal gyrus |
| 421 | −9, −60, 54 | 4.52 | 0.0021 | Bilateral precuneus, spanning L superior parietal lobule, bilateral middle cingulate |
| Right lobule VIIIb | ||||
| 1236 | −57, −21, 18 | 5.08 | 2.51 × 10−6 | L supramarginal gyrus, spanning bilateral precuneus, L superior parietal lobule, L superior temporal gyrus, L postcentral gyrus, L middle temporal gyrus, R superior parietal lobule, L insula, L Rolandic operculum |
Regions of interest from which connectivity was calculated appear above the significant cluster coordinates, statistics, and brain regions. A flexible factorial model was utilized in SPM12, with group and gender as factors, age and framewise displacement as covariates, and seven MCCB cognitive domains as predictors of interest. Group × MCCB domain interaction terms were also included. Results were masked with significant clusters resulting from t-tests and thresholded at uncorrected p < 0.001 and SPM-defined cluster qFDR < 0.0056. Regions were identified using xjView.