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. 2020 Nov 18;21(22):8726. doi: 10.3390/ijms21228726

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Axonal stimulations relieve miRNAs-mediated mRNAs silencing: role in axonal pathfinding. (i) brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) or Slit-2 stimulation induce miRNA de-repression and gate the translation of cytoskeleton regulators (MAP1B, CALM1, Cofilin-1) thereby regulating outgrowth and steering [41,52,73]; (ii) miR-92 keeps Robo1 silent in pre-crossing commissural axons (CAs), and miRNA de-repression at the midline triggers Robo1 translation and concomitant axon sensitivity to cue [75]; (iii) miR-26 de-repression in axons elicits glycogen synthase kinase-3 beta (GSK3β) local synthesis and this leads to the decrease in axonal outgrowth [76].