Figure 3.

Allelic composition and molecular characteristics of the triple-negative breast cancer (TNBC) samples. Driver mutations are depicted according to the type of mutation (missense, hot spot, frameshift, splicing). Specific mutations already reported in other TNBC studies are shown with the label “known mutation”. Treatment availability for specific mutations is marked with a black frame. The functions of the driver gene were classified as oncogene (OG), tumor suppressor gene (TSG), or ambiguous, according to Vogelstein (2013) and IntOGen [33,34]. Prescription availability (clinical trials or FDA approved) for the specific mutations detected is represented according to molecular pathway targeted; TP53 treatment is under early clinical trials and not currently approved by FDA; genes that participate in immunology pathways were classified as INF-γ (interferon g), T cell inflammation activity (T cell inflamed), and Th1 response (Th1_response). The lower panel shows the annotations of clinical characteristics (stage, OS, PCR), potential targeted treatment availability (target treatment), the use of platinum salts in the neoadjuvant setting (NeoCh), and the presence of tumor-infiltrating lymphocytes (TILs). The pathways in which each gene participates are shown at the right-side panel (see Materials and Methods). The top plots illustrated OS, age at the diagnosis, and TMB.