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. 2020 Nov 19;25(22):5409. doi: 10.3390/molecules25225409

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme of the major histocompatibility complex class I (MHC class I) maturation, ligand binding, and presentation on the cell surface. Abbreviations: Ub, ubiquitin; E1, ubiquitin-activating enzyme; E2, ubiquitin-conjugating enzyme; E3, ubiquitin ligase; TAP, transporter associated with antigen presentation; ERAAP, endoplasmic reticulum aminopeptidase associated with antigen processing; β2m, β2 microglobulin; CD8, the cluster of differentiation 8; TCR, T-cell receptor. Created with BioRender.com.