Table 1.
Year | Target | Results | Factors Responsible for Failure | Reference |
---|---|---|---|---|
2016 | E. coli/Proteus (children diarrhea) | Lack of clinical efficacy of oral phages | Insufficient phage coverage; too low E. coli titers; overgrowth of Streptococcus | [3] |
2017 | P. aeruginosa/E.coli (burn infections) | Trial was stopped because of insufficient efficacy | Decreased titer of phage preparations | [4] |
2020 |
Staphylococcus Streptococcus E. coli P. aeruginosa Proteus (urinary tract infections) |
Success rates similar to placebo (bladder irrigation) | Reduction of the bacterial load caused by bladder irrigation with placebo comparable with the effect of phage preparations | [1] |