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Mechanism of chaperone-controlled regulation of α-synuclein function in mammalian cells. Molecular chaperones (blue, e.g., Hsp70s, Hsp90s, small HSPs) interact with the ~40 amino-terminal residues of α-synuclein, also including crucial Tyr39 (red), thus actively regulating its functional species by shifting conformational equilibria, and therefore actively preventing the transitions towards pathological states.
