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. 2020 Nov 19;11(11):1368. doi: 10.3390/genes11111368

Figure 1.

Figure 1

SWI/SNF alterations and ARID1A protein expression in the sq-BLCA cohort of the TCGA network. (A) Genetic alterations of different subunits of the SWI/SNF complex (including missense mutations, truncating mutations, amplifications and deep deletions). (B) Mutation Mapper illustrating positions of identified ARID1A alterations (nonsense and missense) relative to the protein sequence and domains (green and red box). Protein domains are indicated according to PFAM: green box: ARID domain; red box: BAF250_C domain. (C) Mutational frequencies of analyzed subunits of the SWI/SNF complex. (D) Box plots illustrating ARID1A protein expression classified by ARID1A mutations. BAF (dark blue): BRG1/BRM-associated factor; PBAF (light blue): polybromo-associated BAF; MUT: mutated; WT: wildtype. * p < 0.05.