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. 2020 Nov 19;11(11):1368. doi: 10.3390/genes11111368

Figure 2.

Figure 2

Protein expression of subunits of the SWI/SNF complexes BAF and PBAF in squamous-differentiated bladder cancers (sq-BLCA). (A) H&E and immunohistochemical staining of seven subunits of the SWI/SNF complex are shown for a representative tissue core with ARID1A mutation (c.4005-2A>G, p.(?)). Black scale bar: 100 µM. For further immunohistochemical ARID1A staining according to the range of Immune Reactive Scores (IRSs) see Supplementary Figure S3. (B) Box plot graphs show overall distribution of IRS staining results of subunits for urothelial cancers with squamous components (MIX SCC) and pure squamous cancers (SCC). The numeric values correspond to the median value. (C) Frequencies of expression loss (IRS ≤ 2) shown for all analyzed subunits. (D) Expression network illustrating the statistical correlation between analyzed subunits of BAF and PBAF. Only significant (p ≤ 0.05) spearman correlations (r-values as indicated) are shown. Dark blue: component of the BAF complex; light blue: component of the PBAF complex; * p < 0.05.