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. 2020 Nov 18;9(11):3706. doi: 10.3390/jcm9113706

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Longitudinal magnetic resonance imaging (MRI) in Group I, during 28 days of bleomycin-induced lung injury. (A) Representative MRI images of lungs from rats challenged by i.t. administration of bleomycin (or saline as controls), on day 7, 14, 21, and 28 post-challenge. Yellow arrows point out identified lesions (B) MRI defined Lung-ROIs and (C) UTE_SHORT and UTE_LONG defined regions in yellow and blue, respectively. Quantification of the lesion signal assessed by the two different MRI sequences was calculated for (D) “edema” signal indicating peak inflammation in bleomycin challenged rats at day 7, while (E) the calculated “tissue” signal appears to peak at day 28.

Longitudinal magnetic resonance imaging (MRI) in Group I, during 28 days of bleomycin-induced lung injury. (A) Representative MRI images of lungs from rats challenged by i.t. administration of bleomycin (or saline as controls), on day 7, 14, 21, and 28 post-challenge. Yellow arrows point out identified lesions (B) MRI defined Lung-ROIs and (C) UTE_SHORT and UTE_LONG defined regions in yellow and blue, respectively. Quantification of the lesion signal assessed by the two different MRI sequences was calculated for (D) “edema” signal indicating peak inflammation in bleomycin challenged rats at day 7, while (E) the calculated “tissue” signal appears to peak at day 28.