Table 4.
CCS values for IAPP variants in Å2. For some ions, two conformations could be detected.
| Construct | 1+2 | 1+3 | 1+4 | 2+4 | 2+5 |
|---|---|---|---|---|---|
| A25P | 545.2 ± 4.4 | 550.0 ± 7.8 | 666.7 ± 13.1 | 880.0 ± 2.3 | 983.1 ±32.1 |
| 551.7 ± 13.4 | 883.6 ± 14.6 | ||||
| S28P | 544.5 ± 5.2 | 546.5 ± 5.7 | 675.0 ± 1.3 | 881.8 ± 2.1 | 981.3 ± 3.7 |
| 544.7 ±14.4 | 859.5 ± 0.0 | ||||
| S29P | 552.5 ± 3.9 | 542.8 ± 10.5 | 672.3 ± 4.4 | 885.1 ± 8.8 | 937.4 ± 9.1 |
| 544.7 ± 14.4 | |||||
| A25P-S28P | 550.5 ± 3.8 | 542.9 ± 7.9 | 680.2 ± 12.7 | 881.9 ± 2.8 | 878.5± 13.4 |
| 537.7 ± 9.6 | |||||
| A25P-S29P | 551.8 ± 3.1 | 546.5 ± 4.8 | 665.9 ± 26.3 | 896.1± 2.3 | 1004.7 ± 2.9 |
| 544.7 ± 14.4 | 890.7± 10.1 | ||||
| S28P-S29P | 553.3 ± 5.9 | 551.7 ± 8.4 | 616.6 ± 7.0 | 885.2 ± 4.6 | 979.9 ±10.2 |
| 544.7 ± 14.4 | 929.3 ± 15.4 | ||||
| hIAPP | 544.7 ± 4.6 | 551.1 ± 8.1 | 673.0 ± 11.4 | 864.0 ± 9.9 | 1005.9 ± 10.4 |
| 552.9 ± 12.2 | 863.0 ± 21.1 |