Table 8.
Odds ratio (OR) and 95% confidence interval (CI) of the clinicopathological characteristics and MMP-11 rs131451 genotypic frequencies in 175 patients with prostate cancer with biochemical recurrence.
| Variable | Genotypic Frequencies | |||
|---|---|---|---|---|
| rs131451 | TT (n = 58) | TC + CC (n = 117) | OR (95% CI) | p-Value |
| Pathologic Gleason grade group | ||||
| 1 + 2 + 3 | 42 (72.4%) | 75 (64.1%) | 1.00 | p = 0.272 |
| 4 + 5 | 16 (27.6%) | 42 (35.9%) | 1.470 (0.738–2.927) | |
| Clinical T stage | ||||
| 1 + 2 | 51 (87.9%) | 81 (69.2%) | 1.00 | p = 0.007 * |
| 3 + 4 | 7 (12.1%) | 36 (30.8%) | 3.238 (1.340–7.824) | |
| Pathologic T stage | ||||
| 2 | 13 (22.4%) | 27 (23.1%) | 1.00 | p = 0.922 |
| 3 + 4 | 45 (77.6%) | 90 (76.9%) | 0.963 (0.454–2.043) | |
| Pathologic N stage | ||||
| N0 | 48 (82.8%) | 89 (76.1%) | 1.00 | p = 0.312 |
| N1 | 10 (17.2%) | 28 (23.9%) | 1.510 (0.677–3.370) | |
| Seminal vesicle invasion | ||||
| No | 32 (55.2%) | 56 (47.9%) | 1.00 | p = 0.363 |
| Yes | 26 (44.8%) | 61 (52.1%) | 1.341 (0.713–2.522) | |
| Perineural invasion | ||||
| No | 5 (8.6%) | 10 (8.5%) | 1.00 | p = 0.987 |
| Yes | 53 (91.4%) | 107 (91.5%) | 1.009 (0.328–3.103) | |
| Lymphovascular invasion | ||||
| No | 39 (67.2%) | 70 (59.8%) | 1.00 | p = 0.341 |
| Yes | 19 (32.8%) | 47 (40.2%) | 1.378 (0.711–2.670) | |
| D’Amico classification | ||||
| Low/Intermediate risk | 26 (44.8%) | 31 (26.5%) | 1.00 | p = 0.015 * |
| High risk | 32 (55.2%) | 86 (73.5%) | 2.254 (1.164–4.364) | |
The ORs analyzed by their 95% CIs were estimated by logistic regression models. * p-value < 0.05 as statistically significant.