Figure 2.

Overview particle detection techniques. Established (top part) and emerging (lower part) particle detection techniques are summarized according to their size measurement range. Their applicable size range is illustrated by the logarithmic scale at the top and the detection gap around 1 µm is highlighted by a grey bar. Further the techniques are classified into ensemble, single particle, and separation techniques. Stars indicate their current state: * emerging technique; ** established and often used techniques for pharmaceutical applications; *** techniques mentioned in US Pharmacopeia. RMM = Resonant Mass Measurement, DISC = Disc based centrifugation, TRPS = Tunable Resistive Pulse Sensing, STEP = Space- and Time-resolved Extinction Profile.