Figure 6.

Tunable resistive pulse sensing technology (TRPS): instrument, specific pores, and measurement principle. (A) Configuration of the qNano instrument using the TRPS technology (Izon Science Ltd.) zooming from the complete device (left) to the specimen with the tunable nanopore (right). Image adapted with permission from a product of Izon Science Ltd., 2020. (B) Schematic illustration of the measurement principle of the qNano instrument. The suspended particles in the upper compartment pass through the pore and cause the resistive pulse. There are three options to adjust the instrument for optimal settings for the specific sample: mechanical pore stretching, pressure difference adjustment, and the applied direct current voltage (right).