Table 2.

Testing candidate SNPs in a validation cohort. DNA samples from a further 37 diabetic ABB cats, 47 normoglycaemic Australian-bred Burmese cats, and 84 Burmese cats from the low-prevalence US population were genotyped at the SNPs implicated by the GWAS. Results were analysed using Plink. A1 indicates the minor allele (i.e., least frequently observed based on the whole sample); F_A and F_U indicate the frequency of the minor allele in the affected and unaffected cats, respectively. The p value is shown calculated using Fisher’s Exact test and Bonferroni correction. No odds ratio could be calculated for SNP2 because the associated allele was not found in the non-diabetic cats.

SNP	A1	F_A	F_U	p Value	OR	Chromosome Position
SNP1	T	0.59	0.38	0.00089	2.4	chrA3: 10995614
SNP2	G	0.29	0.52	0.00043	0.4	chrA3: 134626291
SNP3	C	0.17	0.46	5.35 × 10−6	0.2	chrC1: 23237623
SNP4	C	0.63	0.41	0.0013	2.5	chrC2: 83660325
SNP5	T	0.32	0.49	0.012	0.5	chrC2: 84129862
SNP6	A	0.30	0.34	0.53	0.8	chrC2: 84135537