Table 1.
Summary of the intervention and control.
| MNs Type | Intervention | Control | ||||||
|---|---|---|---|---|---|---|---|---|
| MNs | MNs + Drug | MNs + Other Treatment | Other Treatment + Drug | Drug Application Only | Other Treatment Only | No-Treatment | Placebo | |
| MTS (n = 8) | ||||||||
| Kim, 2009 [47] | √ | - | - | - | √ | - | √ | - |
| Yoo, 2010 [48] | - | √ | - | - | √ | - | - | - |
| Choi, 2011 [49] | - | √ | - | √ | - | - | - | - |
| Khater, 2016 [50] | √ | - | - | - | - | CO2 laser | - | - |
| Spencer, 2016 [51] | √ | √ | ||||||
| Petukhova, 2017 [52] | - | √ | - | - | - | - | - | √ |
| Bao, 2017 [14] | √ | √ | - | - | √ | - | - | - |
| Busch, 2018 [53] | - | √ | - | - | - | - | √ | - |
| MRF (n = 6) | ||||||||
| Shin, 2012 [54] | √ | - | - | - | - | CO2 laser | - | - |
| Jeon, 2013 [55] | √ | - | - | √ | - | - | - | - |
| Ryu, 2013 [56] | √ | - | CO2 laser | - | - | CO2 laser | - | - |
| Chae, 2014 [57] | √ | - | - | √ | - | - | - | - |
| Fatemi Naeini, 2015 [23] | √ | - | - | - | - | - | - | √ |
| Lu, 2017 [58] | √ | - | - | - | - | Superficial dermal insertion | - | - |
| MAP (n = 11) | ||||||||
| Cosman, 2010 [59] | √ | √ | √ | |||||
| Daddona, 2011 [31] | - | √ | - | √ | - | - | - | √ |
| Hirobe, 2015 [32] | - | √ | - | √ | - | - | - | - |
| Kim, 2016 [60] | - | √ | - | - | - | - | - | √ |
| Lee, 2016 [61] | - | √ | - | √ | - | - | - | - |
| Rouphael, 2017 [62] | - | √ | - | √ | - | - | - | √ |
| Park, 2017 [63] | - | √ | - | - | √ | - | - | - |
| Hong, 2018 [64] | √ | √ | - | - | √ | - | - | - |
| Ryu, 2018 [65] | - | √ | - | - | - | Cryotherapy | - | - |
| Fernando, 2018 [66] | - | √ | - | √ | - | Intramuscularly injection | - | √ |
| Spierings, 2018 [67] | √ | √ | ||||||
| Hollow MNs (n = 13) | ||||||||
| Damme, 2009 [26] | - | √ | - | √ | - | - | - | - |
| Laurent, 2010 [68] | - | √ | - | √ | - | - | - | - |
| Pettis, 2011 [69] | - | √ | - | √ | - | - | - | - |
| Frenck, 2011 [70] | √ | √ | ||||||
| McVey, 2012 [27] | - | √ | - | √ | - | - | - | √ |
| Norman, 2013 [71] | - | √ | - | √ | - | - | - | - |
| Levin, 2014 [72] | - | √ | - | √ | - | - | - | - |
| Anand, 2015 [73] | - | √ | - | √ | - | - | - | - |
| Troy, 2015 [74] | - | √ | - | √ | - | - | - | - |
| Rini, 2015 [75] | - | √ | - | √ | - | - | - | - |
| Levin, 2016 [76] | - | √ | - | √ | - | - | - | - |
| Kochba, 2016 [77] | - | √ | - | √ | - | - | - | - |
| Vescovo, 2017 [78] | - | √ | - | √ | - | - | - | - |
-, that intervention was not used; √, that intervention was used; MAP, microneedle array patch; MN, microneedle; MRF, microneedle radiofrequency; MTS, microneedle therapy system.