TABLE 2.
Cerebral hemodynamic and metabolism measures for control and CHD groups
| Variables | Control | Stage | BiV | TGA | SV |
|---|---|---|---|---|---|
| SaO2, % | 98.5 (98.0, 100.0) | Preoperative | 96.0 (90.0, 100.0) | 93.0 (87.0, 96.0) | 98.0 (95.0, 98.0) |
| Postoperative | 98.5 (98.0, 99.0) | 99.0 (97.0, 99.5) | 85.0 (82.0, 88.0) | ||
| SO2, % | 69.2 (65.8, 72.3) | Preoperative | 59.0 (57.6, 60.4) | 48.9 (44.7, 56.2) | 63.8 (60.8, 65.7) |
| Postoperative | 60.0 (51.8, 64.1) | 62.6 (53.0, 66.9) | 47.2 (41.2, 52.0) | ||
| OEF | 0.4 (0.3, 0.4) | Preoperative | 0.5 (0.5, 0.6) | 0.6 (0.5, 0.6) | 0.5 (0.4, 0.5) |
| Postoperative | 0.5 (0.5, 0.6) | 0.5 (0.4, 0.6) | 0.6 (0.5, 0.7) | ||
| CBV, mL/100g | 1.8 (1.7, 2.1) | Preoperative | 2.3 (2.0, 2.6) | 2.4 (1.8, 2.6) | 2.1 (1.8, 2.3) |
| Postoperative | 2.2 (2.0, 2.6) | 2.0 (1.7, 2.2) | 1.9 (1.6, 2.3) | ||
| CBFi, ×10−6 mm2/s | 3.5 (3.1, 4.4) | Preoperative | 3.7 (2.8, 4.4) | 2.9 (2.5, 3.5) | 2.8 (2.1, 3.4) |
| Postoperative | 3.4 (2.8, 3.7) | 2.6 (2.3, 3.7) | 2.8 (2.2, 3.2) | ||
| CMRO2i, ×10−5 mL O2/dL· mm2/s | 3.2 (2.5, 4.0) | Preoperative | 2.3 (2.2, 3.0) | 3.2 (2.5, 4.0) | 2.5 (2.0, 2.9) |
| Postoperative | 2.6 (1.9, 3.7) | 3.1 (2.1, 3.3) | 2.6 (2.1, 3.0) | ||
| Hemoglobin, g/dL | 16.8* | Preoperative | 10.7 (10.4, 12.4) | 13.7 (12.2, 14.8) | 15.6 (13.4, 17.8) |
| Postoperative | 12.5 (11.3, 12.8) | 14.7 (12.0, 16.6) | 14.1 (13.0, 14.8) | ||
| Hematocrit, % | NA* | Preoperative | 31.6 (31.0, 35.8) | 40.6 (37.9, 44.5) | 47.5 (41.2, 53.5) |
| Postoperative | 36.2 (34.0, 39.2) | 44.9 (38.4, 50.0) | 43.8 (39.7, 45.8) | ||
| Temperature, °C | NA | Preoperative | 36.8 (36.7, 36.9) | 36.6 (36.5, 37.2) | 36.6 (36.5, 37.0) |
| Postoperative | 36.8 (36.7, 36.9) | 36.9 (36.8, 36.9) | 36.8 (36.6, 36.9) |
The values for all groups are presented as median (interquartile range). BiV, Biventricular heart disease without transpostion of the great arteries; TGA, d-transposition of the great arteries; SV, single-ventricle heart disease; SaO2, arterial saturation; SO2, cerebral oxygen saturation; OEF, cerebral oxygen extraction fraction; CBV, cerebral blood volume; CBFi, cerebral blood flow index; CMRO2i, cerebral oxygen metabolism index, NA, not applicable.
*
In control neonates, a hemoglobin level was assumed based on published normative data.18