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. 2020 Nov 24;14:5129–5141. doi: 10.2147/DDDT.S268796

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© 2020 Tang et al.

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Michaelis–Menten curves of the enzymatic activity of the recombinant wild-type CYP3A4*1 and 22 variants toward sildenafil N-demethylation (each point represents the mean ±SD of three parallel experiments).