Table 3.
Pharmacokinetics Parameters of Triamcinolone Acetonide in Aqueous Humor After Topical Instillation
| Formulations | Cmax | AUC0→t | MRT | Tmax | VRT |
|---|---|---|---|---|---|
| mg·L−1 | h·h·mg·L−1 | h | h | h2 | |
| PLGA NPs | 0.60 ± 0.14 | 0.82 ± 0.22 | 1.71 ± 0.12 | 1.5 ± 0 | 0.63 ± 0.21 |
| 2-HP-β-CD/PLGA NPs | 11.51 ± 1.26** | 21.29 ± 1.64** | 1.93 ± 0.15* | 1.5 ± 0 | 0.75 ± 0.36 |
| Trehalose/PLGA NPs | 1.11 ± 0.52* | 1.25 ± 0.55* | 1.78 ± 0.07 | 1.5 ± 0 | 0.85 ± 0.15 |
| Chitosan oligosaccharide/PLGA NPs | 0.62 ± 0.26 | 0.84 ±0.43 | 1.69 ± 0.10 | 1.5 ± 0 | 0.71 ± 0.10 |
Notes: Data are expressed as mean ± standard deviations (n = 6). *P < 0.05, **P < 0.01, compared to the corresponding parameters of PLGA NPs.
Abbreviations: NPs, nanoparticles; 2-HP-β-CD, 2-hydroxypropyl-β-cyclodextrin; Cmax, peak concentrations; AUC0→t, area under curve; MRT, mean residence time; Tmax, time to reach maximum concentration; VRT, variance of residence time.