Skip to main content
. Author manuscript; available in PMC: 2020 Nov 28.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2018 Oct 15;103(3):719–727. doi: 10.1016/j.ijrobp.2018.10.007

Fig. 5.

Fig. 5.

Antibody mediated blockade of interleukin 6 (IL-6) signaling exacerbates intestinal fibrosis post-irradiation (IR). (A) Kaplan-Meier survival analysis of isotype and anti-IL-6R–treated mice after 18 Gy. (B) Body weights of isotype and anti-IL-6R–treated mice post 18 Gy. (C) Quantification of fibrillar collagen content performed in ImageJ. (D) Hematoxylin and eosin (H&E), Masson’s trichrome, and picrosirius red stained sections of intestine from control, 18 Gy + isotype treated mice, and 18 Gy + anti-IL-6R–treated mice 2 months post-IR (20 magnification, scale bar 100 μm). P < .01 (**), P < .0001 (****).