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. 2020 Nov 19;12(11):3444. doi: 10.3390/cancers12113444

Figure 2.

Figure 2

L1 is exclusively expressed at the invasive front of human colorectal cancer (CRC) tissue in cells expressing β-catenin in their nuclei. (A) Immunohistochemical staining of human CRC tissue for L1. Note the preferential localization of L1 in invasive areas of the tumor (black arrowheads), but not in the inner more differentiated areas of the tumor. (B) In contrast to L1 localization, a serial tissue section stained with anti β-catenin antibody displays a uniform staining of the same CRC tissue area. (C) Enlarged picture of the boxed area in (A) showing the membranal localization of L1. Single CRC cells invading into the stroma could also be seen (red arrowheads). (D) Magnified picture of the boxed area shown in (B) localizing β-catenin staining in both the cytoplasm and nuclei of CRC tissue cells and in the nuclei of single invasive cells (red arrowheads) at the tumor tissue edge [19]. Scale bar: (A,B) 375 μm, (C,D) 75 μm.