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. 2020 Nov 19;12(11):3444. doi: 10.3390/cancers12113444

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Genes induced by L1 in CRC cells include intestinal stem cell signature genes. (A) Insulin like growth factor receptor 2 (IGFBP-2) staining of CRC tissue revealed strong staining of the tumor tissue throughout the tissue, while in the adjacent normal mucosa, IGFBP-2 staining was exclusively confined to the bottom of colonic crypts (black arrowheads). (B) The intestinal stem cell signature gene secreted modular calcium-binding matricellular protein-2 (SMOC-2) was detected at the bottom of colonic crypts in normal colonic mucosa (red arrowheads). (C) In CRC tissue, SMOC-2 was localized in more differentiated areas of the tumor with stronger staining of invasive areas of the tumor (blue arrowhead) [44,46]. Scale bar: (A) 250 μm, (B) 50 μm, (C) 100 μm.