Table 2.
Descriptive statistics of circulating bile acids levels in fasting and postprandial states.
| Fasting State (n = 71) | Postprandial State (n = 71) | Fold Change from Fasting State | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BAs (µM) | Median | Q1 | Q3 | Mini | Maxi | Interindividual Variability | Median | Q1 | Q3 | Mini | Maxi | Interindividual Variability | |
| Primary BAs | 1.451 | 0.859 | 2.497 | 0.289 | 10.84 | 1.6 | 3.185 | 2.581 | 4.486 | 0.694 | 11.95 | 1.3 | 2.2 |
| Unconj | |||||||||||||
| CA | 0.110 | 0.040 | 0.380 | < | 3.050 | 2.3 | 0.020 | 0.010 | 0.040 | 0.010 | 0.300 | 1.9 | −5.5 |
| CDCA | 0.310 | 0.150 | 0.640 | 0.010 | 3.050 | 1.8 | 0.050 | 0.030 | 0.090 | 0.010 | 1.340 | 2.7 | −6.2 |
| Taurine-Conj | |||||||||||||
| TCA | 0.020 | 0.010 | 0.050 | < | 0.890 | 3.4 | 0.080 | 0.040 | 0.140 | < | 1.060 | 1.9 | 4.0 |
| TCDCA | 0.090 | 0.040 | 0.200 | < | 1.030 | 1.8 | 0.380 | 0.190 | 0.700 | 0.050 | 3.020 | 1.6 | 4.2 |
| Glycine-Conj | |||||||||||||
| GCA | 0.070 | 0.040 | 0.150 | 0.010 | 0.680 | 1.6 | 0.270 | 0.150 | 0.370 | 0.060 | 1.310 | 1.5 | 3.9 |
| GCDCA | 0.500 | 0.360 | 0.930 | 0.070 | 2.790 | 1.4 | 2.020 | 1.460 | 3.160 | 0.520 | 9.050 | 1.3 | 4.0 |
| Secondary BAs | 1.095 | 0.662 | 1.580 | 0.085 | 5.653 | 1.4 | 1.617 | 1.247 | 2.580 | 0.190 | 8.026 | 1.4 | 1.5 |
| UnConj | |||||||||||||
| DCA | 0.420 | 0.180 | 0.660 | 0.020 | 2.430 | 1.5 | 0.180 | 0.080 | 0.280 | 0.010 | 0.860 | 1.5 | −2.3 |
| LCA | < | < | < | < | 0.010 | 5.0 | 0.010 | 0.010 | 0.020 | < | 0.120 | 1.8 | na |
| HDCA | < | < | < | < | 0.110 | 11.5 | < | < | < | < | 0.210 | na | na |
| HCA | < | < | < | < | 0.090 | 4.7 | < | < | < | < | 0.100 | 4.3 | na |
| Taurine-Conj | |||||||||||||
| TDCA | 0.090 | 0.060 | 0.120 | < | 3.600 | 4.9 | 0.160 | 0.100 | 0.250 | < | 4.020 | 2.6 | 1.8 |
| THDCA | < | < | < | < | 0.060 | na | < | < | < | < | 0.030 | na | na |
| TLCA | < | < | < | < | 0.010 | 5.0 | 0.010 | 0.010 | 0.020 | < | 0.120 | 1.8 | na |
| Glycine-Conj | |||||||||||||
| GDCA | 0.190 | 0.070 | 0.280 | < | 1.000 | 1.5 | 0.570 | 0.360 | 0.910 | 0.040 | 3.910 | 1.5 | 3 |
| GHDCA | < | < | < | < | na | < | < | < | < | < | na | na | |
| GLCA | 0.010 | < | 0.010 | < | 0.050 | 1.7 | 0.070 | 0.040 | 0.120 | < | 0.240 | 1.4 | 7 |
| Tertiary BAs | 0.488 | 0.304 | 0.650 | 0.025 | 1.617 | 1.3 | 0.958 | 0.730 | 1.130 | 0.288 | 2.286 | 1.2 | 1.96 |
| Unconj | |||||||||||||
| UDCA | 0.060 | 0.030 | 0.110 | < | 0.550 | 1.7 | 0.020 | 0.010 | 0.040 | < | 0.380 | 2.2 | −3 |
| Taurine-Conj | |||||||||||||
| TUDCA | < | < | 0.010 | < | 0.060 | 2.9 | 0.010 | < | 0.020 | < | 0.120 | 1.7 | na |
| Glycine-Conj | |||||||||||||
| GUDCA | 0.090 | 0.060 | 0.180 | < | 1.420 | 1.9 | 0.270 | 0.160 | 0.440 | 0.030 | 2.100 | 1.6 | 3.0 |
| Sulfo-Conjugated | 0.300 | 0.194 | 0.470 | < | 1.543 | 1.4 | 0.571 | 0.416 | 0.783 | 0.017 | 1.530 | 1.3 | 1.9 |
| CA-3S | < | < | < | < | < | na | < | < | < | < | < | na | na |
| CDCA-3S | < | < | < | < | 0.020 | 3.5 | < | < | < | < | 0.010 | na | na |
| DCA-3S | < | < | 0.010 | < | 0.040 | 2.4 | < | < | 0.010 | < | 0.040 | 2.9 | na |
| LCA-3S | < | < | 0.010 | < | 0.070 | 3.0 | < | < | < | < | 0.040 | 4.3 | na |
| TLCA-3S | 0.100 | 0.050 | 0.170 | < | 0.550 | 1.5 | 0.150 | 0.100 | 0.260 | < | 0.800 | 1.4 | 1.5 |
| GLCA-3S | 0.190 | 0.110 | 0.270 | < | 1.100 | 1.5 | 0.390 | 0.240 | 0.550 | < | 1.150 | 1.3 | 2.1 |
| UDCA-3S | < | < | < | < | < | na | < | < | < | < | < | na | na |
| TUDCA-3S | < | < | < | < | < | na | < | < | < | < | < | na | na |
| GUDCA-3S | < | < | < | < | 0.020 | na | < | < | < | < | 0.020 | 10.6 | na |
| Total BAs | 2.823 | 1.974 | 4.862 | 0.799 | 13.55 | 1.4 | 5.696 | 4.355 | 7.591 | 2.104 | 17.59 | 1.2 | 2.0 |
| Unconj BAs | 0.962 | 0.572 | 1.882 | 0.099 | 11.97 | 1.7 | 0.309 | 0.173 | 0.418 | 0.043 | 2.660 | 1.6 | −3.2 |
| Conj BAs | 1.569 | 1.081 | 2.527 | 0.264 | 5.292 | 1.3 | 4.606 | 3.526 | 6.778 | 1.780 | 15.620 | 1.3 | 2.9 |
| C4 | 2.972 | 0.036 | 8.746 | < | 33.35 | 1.8 | 5.645 | 1.045 | 10.800 | < | 31.670 | 1.6 | 1.9 |
Interindividual variability expressed as the ratio of 95th percentile/5th percentile; Conj: conjugated; Unconj: unconjugated; Taurine-conj: Taurine-conjugated; Glycine-Conj: Glycine-conjugated. na indicates: not applicable.