Virological evolution and emergence of resistance-associated mutations (arrows pointing downwards) of our patient since initiation of antiretroviral treatment. Abbreviations: ART: antiretroviral treatment, 3TC: lamivudine, D4T: stavudine, NFV: nelfinavir, SSITT: Swiss Spanish Intermittent Treatment Trial, FAPV/r: fosamprenavir/ritonavir, TDF: tenofovir disoproxil-fumarate, FTC: emtricitabine, (*) add-on raltegravir for one month, DRV/r: darunavir/ritonavir, ETV: etravirine, TAF: tenofovir alafenamide, LOQ: level of quantification. The persisting M184V/I mutation is highlighted in bold.