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. 2020 Nov 19;21(22):8751. doi: 10.3390/ijms21228751

Figure 3.

Figure 3

Working hypothesis, namely, the role of the ECS, on neuroinflammation in AD. Inflammatory cytokines activate CB2 signaling in microglia, which, in turn, initiates a feedback mechanism to finish this process. Due to the chronic inflammatory process in the AD brain, the CB2 pathway remain active; however, it fails to reduce inflammation.